1. Chemical Characteristics

  • Chemical Name: 3α,7α-Dihydroxy-5β-cholanic Acid
  • CAS Number: 474-25-9
  • Molecular Formula: C₂₄H₄₀O₄
  • Molecular Weight: 392.57
  • Physical Properties:
    • Appearance: Colorless needle-like crystals, odorless, with a bitter taste.
    • Solubility: Almost insoluble in water; readily soluble in ethanol and glacial acetic acid; slightly soluble in chloroform.

2. Pharmacological Actions

  • Cholesterol Gallstone Dissolution:
    • Inhibits HMG-CoA reductase activity, reducing cholesterol synthesis.
    • Enhances bile acid secretion, lowering cholesterol saturation in bile and promoting dissolution in micellar form.
  • Lipid Metabolism Regulation:
    • Reduces cholesterol secretion by liver cells.
    • Decreases intestinal cholesterol reabsorption, improving blood lipid profiles.
  • Choleretic and Antibacterial Effects:
    • Stimulates bile secretion (choleresis).
    • Inhibits growth of biliary tract pathogens, including Staphylococcus and Streptococcus.

3. Production and Supply

  • Primary Manufacturer:
    • Qinghai Xidu Pharmaceutical Co., Ltd.: Supplies raw pharmaceutical material (CAS: 474-25-9).
  • Packaging: Customizable specifications available.